LSU vs. South Carolina odds, spread: 2024 college football picks, Week 3 predictions based on proven model

The 16th-ranked LSU Tigers will face the South Carolina Gamecocks in SEC play on Saturday in Columbia, S.C. It is LSU's conference opener. The Tigers (1-1), seeking their third consecutive 10-win season, beat Nicholls 44-21 last Saturday. The Gamecocks (2-0), who finished 5-7 last year, have not won more than 10 games in a season since going 11-2 in 2013.

Kickoff at Williams-Brice Stadium is scheduled for 12:00 p.m. ET. LSU is averaging 399.5 yards per game, while South Carolina is averaging 270. The Tigers are favored by 6.5 points in the latest LSU vs. South Carolina odds according to the SportsLine consensus, while the over/under for total points is 49.5. Before you make your LSU vs. South Carolina picks, check out the college football predictions from the SportsLine Projection Model.

The model simulates every FBS college football game 10,000 times. Since its launch, it has returned over $2,000 on $100 bettors with its top-rated college football picks against the spread. It also has a profitable season going 13-9 on top-rated spread picks and started this season 4-0 on over/under picks. Everyone who has followed it has seen strong returns.

The model has focused on LSU vs. South Carolina. You can head over to SportsLine to check out the picks. Here are several college football betting odds for the spread, money line and over/under for the game:

• LSU vs. South Carolina spread: LSU -6.5
• LSU vs. South Carolina over/under: 48 points
• LSU vs South Carolina – Line: LSU -240, South Carolina +193
• LSU: The Tigers have exceeded the total points in 11 of their last 13 games (+8.80 units)
• SC: The Gamecocks have reached the moneyline in the first quarter in nine of their last twelve games (+11.40 units)
• LSU vs. South Carolina Tips: See Tips at SportsLine

Why you should support LSU

Sophomore wide receiver Aaron Anderson is making his mark this season, having five catches for 63 yards in a 44-21 win over Nicholls last Saturday. In the season-opening 27-20 loss to Southern Cal, Anderson had five pass catches for 64 yards and a touchdown, including a long one of 41 yards. For his career, Anderson has 22 catches for 186 yards (8.5 avg.) and a touchdown.

Veteran defensive end Sai'vion Jones has been a beast on defense, leading the team with two sacks for eight yards, both of which came in the opening game against USC. In two games, he recorded seven tackles, including four solo, with one forced fumble and one pass defense. In four seasons with the Tigers, he recorded 65 tackles, including 24 solo, with nine sacks, two forced fumbles and four pass defenses. See which team to choose here.

Why you should support South Carolina

Wide receiver Mazeo Bennett Jr. has had a great start to his college career. In the opening win against Old Dominion (23-19), the freshman caught two passes for 18 yards. In the 31-6 win against Kentucky, he caught three passes for 63 yards and scored one point. With 16.2 yards per pass caught, he ranks 19th in the SEC.

The Gamecocks' defense has been stellar. They have two edge rushers who have combined for six sacks for 45 yards. Freshman Dylan Stewart has 2.5 sacks for 26 yards and two forced fumbles. Senior Kyle Kennard has 3.5 sacks for 19 yards and two forced fumbles. After two games, South Carolina has 10 sacks and six forced fumbles. See which team to pick here.

How to make your predictions for LSU vs. South Carolina

SportsLine's model is leaning over overall, predicting 48 combined points. It also says one side of the range represents the better value. You can only get the pick at SportsLine.

So who will win in the LSU vs. South Carolina game and which side of the spread offers better value? Visit SportsLine now to see which side of the LSU vs. South Carolina spread you should jump on with the advanced model that's gained over $2,000 on its FBS college football picks since its inception and find out.