Matthew Perry appeared to “freeze” after a “large” dose of ketamine 2 weeks before his death

Popular “Friends” star Matthew Perry appeared to “freeze” after a doctor – who was charged in connection with his death on Thursday – injected him with a “large dose” of ketamine just two weeks before his overdose.

Salvador Plascencia was charged, along with another doctor, Mark Chavez, Perry's longtime assistant Kenneth Iwamasa, alleged street dealer Erik Fleming and Jasveen Sangha, the so-called “Ketamine Queen of Los Angeles,” for defrauding the 54-year-old actor of thousands of dollars to buy vials of ketamine that cost just $12, authorities said.

Plascencia, 42, had a license to prescribe and administer the powerful sedative but took the opportunity to capitalize on Perry's well-documented drug abuse. According to one indictment, she even texted Iwamasa, “I wonder how much this idiot is going to pay for ketamine,” as the actor continued to lose control of his drugs.

But 16 days before he was found dead in a hot tub at his California home in October, the doctor appeared to backtrack when Perry suffered a seizure in which he appeared to “freeze” and his blood pressure skyrocketed after being given a “large dose” of ketamine.

“We must not do this again,” he told 59-year-old Iwamasa.

Iwamasa, who lived with Perry and had been his assistant since 1994, administered at least 27 ketamine injections to his boss in the last five days of his life – including three that resulted in his “death and serious bodily harm,” according to prosecutors.

At the time of his death, Perry had been undergoing weeks of ketamine therapy for depression. When doctors at the clinic refused to increase his ketamine dosage, the “Fools Rush In” star turned to Plasencia, Drug Enforcement Administration director Anne Milgram said Thursday.

Plasencia asked Chavez, 54, for help in obtaining the medication for Perry, she added.

From September until Perry's death on October 28, Plasencia and Chavez are said to have supplied him with about 20 vials of ketamine in exchange for around $55,000 in cash. Perry had to shell out $2,000 for a $12 vial of the drug.

He also expressed a desire to become Perry's drug contact, authorities said. Iwamasa, who had no medical training, also injected Perry with the drug at Plasencia's direction.

Plascencia allegedly sold Iwamasa an additional $6,000 worth of ketamine, despite knowing that Perry's addiction was potentially fatal.

Authorities believe Perry's final, fatal dose of ketamine was supplied by Sangha.

Plascencia and Sangha are both charged with conspiracy to distribute ketamine.

Plasencia is additionally charged with seven counts of trafficking in ketamine and two counts of altering or falsifying documents or records in connection with a federal investigation.

Sangha, who allegedly operated a drug stash, was also charged with maintaining a drug-containing premises, possession of methamphetamine with intent to resell, possession of ketamine with intent to resell and five counts of resale of ketamine.

Fleming, Iwamasa and Chavez each accepted a plea deal in which they admitted to conspiracy to distribute ketamine and conspiracy to distribute ketamine resulting in death.