Odds, tips and predictions for the game San Diego Padres vs Seattle Mariners

The San Diego Padres (82-64) and Seattle Mariners (73-72) finish a 2-game interleague series on Wednesday. First pitch from T-Mobile Park is scheduled for 9:40 p.m. ET (FS1). Let's check out FanDuel Sportsbook's odds around the Padres vs. Mariners Opportunities and place your best bets with our expert MLB tips and predictions.

Season series: Mariners lead 2-1

The Padres scored a 7-3 win over the Mariners behind RHP in Tuesday's interleague opener Yu Darvish as a slight underdog (+112) as the over (7) hit.

San Diego has won 5 of their last 8 games and is 3-1 in their last 4 away games. They are 18-7 in their last 25 away games.

In interleague play, San Diego has won 4 of its last 5 games and is 11-4 in its last 15 tries against the American League. The Over has scored in 3 consecutive games and is 10-2-1 in its last 13 tries against AL teams.

Despite Tuesday's setback, Seattle has won 4 of its last 6 games at the Mariners. Over has struck out in its last 2 games and is 8-3-1 in its last 12 games.

Against the National League, the M's are only 5-9 in their last 14 attempts, but 14-5 in their last 19 home interleague games.

Expected Padres starters at Mariners

RHP Michael King against RHP Bryan Woo

King (12-8, 3.10 ERA) is making his 28th start and 29th appearance. He has a 1.21 WHIP, 3.3 BB/9 and 10.6 K/9 in 156 2/3 IP.

• Last start: Win, 6 IP, 1 ER, 6 H (1 solo HR), 1 BB, 8 K in the 5-1 home win against the San Francisco Giants on Friday
• 2024 Road Splits: 8-3, 2.86 ERA, 85 IP, 27 ER, 9 HR, 1.18 WHIP, .222 opposing batting average (OBA), 30 BB, 83 K in 14 starts (15 appearances)
• Career vs. Mariners: 0-1, 2.08 ERA, 8 2/3 IP, 2 ER, 0 HR, 1.04 WHIP, 13.5 K/9 in 3 appearances (1 start)

Woo (7-2, 2.36 ERA) makes his 19th start. He has a WHIP of 0.85, 0.8 BB/9 and 7.0 K/9 in 99 IP.

• Last start: Win, 6 IP, 2 ER, 6 H, 0 BB, 9 K in the 16-3 road win against Oakland A's on August 4
• 2024 Home Splits: 4-0, 1.50 ERA, 42 IP, 7 ER, 2 HR, 0.67 WHIP, .170 OBA, 3 BB, 35 K in 7 starts
• Has never played against the Padres

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Padres at Mariners odds

Provided by FanDuel Sportsbook; for a complete list visit the USA TODAY sports scores and betting odds hub. Odds last updated at 3:55 a.m. ET.

• Moneyline (ML): Padres -108 (bet $108 to win $100) | Mariners -108 (bet $108 to win $100)
• Running Line (RL)/Against the Spread (ATS): Padres -1.5 (+168) | Mariners +1.5 (-205)
• Over/Under (O/U): 6.5 (O: -122 | U: +100)

Tips and predictions for Padres at Mariners

forecast

Mariners 3, Padres 2

Money line

The Sailor (-108) are worth watching behind Woo in the series finale. The right-handed starter from Seattle was nearly unhittable at T-Mobile Park, posting an astonishing 4-0 record with a 1.50 ERA in 42 IP in 7 starts.

While Woo's numbers make the M's look like a sure thing, King has also been solid for the Padres (-108), and the odds suggest this is truly a fluke. But given Woo's slightly better splits at home than King's numbers on the road, you have to side with Seattle.

Running Line/Against the Spread

Mariners +1.5 (-205) is just too expensive on the run line if you need insurance and are perhaps a little spooked by their loss in Tuesday's interleague series opener.

However, you can't risk more than twice your potential winnings. If you like Seattle, just bet on it directly.

HAPPEN.

Over/Under

UNDER 6.5 (+100) is worth an even-odds throw since we should have a pitcher's duel in SoDo.

King has excellent splits on the road, 8 wins and a 2.83 ERA, while Woo has a 4-0 record and a 1.50 ERA at home this season. Neither will be taking much. Go deep and feel confident doing so.

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